Nifedipine tablets

nifedipine 30 mg tablets

What is Nifedipine and what is it used for?

Nifedipine is a specific drug used for the treatment of hypertension, as it belongs to the pharmacological class of calcium channel blockers. It has greater functionality on dilation of the arteries, compared to other calcium channel blockers. In fact, it is used for the short-term treatment for various types of angina (in particular in angina pectoris vasospastic or Prinzmetal’s angina)

The modified-release tablets have a hole performed in the compressed membrane with laser technology (OROS technology, osmotic pump used for oral sustained release): the hole allows the controlled and constant release of the active substance, producing benefits both in the treatment of hypertension and of angina pectoris.

Nifedipine, when administered orally, is absorbed by the body very rapidly and almost totally by the intestines, so sudden to guarantee a maximum plasma peak in 30/60 minutes. Although the absorption is very high, bioavailability is approximately around 50% considering the first passage effect characterized by the oxidation and the subsequent inactivation of the active substance. The biological active quota, acts on the surface of the smooth-muscle cells by inhibiting the activity of the active calcium channels. Those channels are responsible for the massive entrance of calcium in the intracellular environment, which is necessary to guarantee al the events that underlie the cell’s contraction.

The muscle relaxant action takes place on a fibro cellular level in the coronary arteries, while the cardiac and skeletal muscles aren’t involved in the process.

The biological action of Nifedipine does translate in vasodilation and decrease in peripheral resistances, with a subsequent reduction of the arterial pressure, the cardiac workload and the request of oxygen.

When the action of Nifedipine is ended, after 2-3 hours, the active substance is removed through the renal pathway.

What you have to know before taking Nifedipine

The administration of Nifedipine needs to be done with particular attention when the patient is following a medical therapy that includes the use of antihypertensive drugs or when the patient suffer from hypotension.

A monitoring of the glycemic levels is essential when Nifedipine is administered to diabetic patients, and in case of hyperglycaemia, is advisable to suspend the therapy.

Also, the dosage of Nifedipine needs to be reviewed when the patient suffer from hepatic impairment, considering the first passage effect which halve the biologically efficient dosage, while a suspension of the therapy needs to be done gradually in order to avoid rebounds.

Severe blood pressure losses, adaption reactions to the therapy (at his initial phase) and the individual sensitivity to Nifedipine, could make the usage of machineries dangerous as well as driving.

It’s important to note how the concomitant assumption of other drugs may alter Nifedipine’s pharmacological properties, so it’s highly advised to consult the specialist if the patients is following another medical treatment.

The side-effects of Nifedipine

The clinical trials shows a good tolerability of the product, with not-so-relevant and transitional adverse reactions.

The side-effects of Nifedipine may include:

  • Headache
  • Nausea
  • Dizziness
  • Warmth sensation
  • Heartburn
  • Increased heart rate
  • Muscle cramp
  • Constipation
  • Cough
  • Sexual related issues

Suggested dosage for Nifedipine

For arterial hypertension and during the treatment of ischemic heart diseases and Raynaud’s syndrome, usually it’s advised to take one capsule for three times a day. Even though this is the suggested dosage for Nifedipine, the therapy is subjected to significant variations in terms of useful and effective dosage. For this reason, the dosage needs to be personalized by the specialist, based on the individual needs of the patient and on the severity of the ongoing disease.

The assumption of Nifedipine needs to be done on an empty stomach, because pharmacokinetic studies showed how food might increase the time required for the plasma peak to reach its maximum.

For more information on Nifedipine 30 mg OROS tablets consult valpharma.com website.